tina huang data scientist tina huang data scientist

Extended Data Fig. I also have a newsletter called Boop's Keyboard! Harris, K. & Nielsen, R. The genetic cost of Neanderthal introgression. (2023, March 1). Patterson, N. et al. 27, 21852193.e6 (2017). Article We tested the affinity of Tutkaul 1 to worldwide ancient and modern populations relative to AG3. The authors thank G. Marciani and O. Jris for comments on archaeology; C. Jeong, M. Spyrou and K. Prfer for comments on genetics; M. OReilly for graphical support for Fig. Disease-modifying, readily available, and easily affordable medical therapies for hypertension are ubiquitous and set a high bar for any new therapeutic. Data Visualization Explained: Candlestick Chart, R Programming for Statistics and Data Science 2020. Content on this website is for information only. Science 366, 708714 (2019). I have an undergraduate degree in pharmacology from the University of Toronto. We use cookies to improve your experience and give you personalized content. BMC Res. 10, 1218 (2019). Tina Huang. Earlier I had practiced a bit of MySQL, but here through this course I got introduced to PostgreSQL. 276, 107319 (2022). USA 110, 22232227 (2013). The suspension was then centrifuged and transferred into a binding buffer as previously described56. Follow Author. 4. 5 Cliches About computer science flow chart You Should Avoid, What Freud Can Teach Us About brief candle in the dark my life in science. Her content is perfect for those who want to learn more about the industry and how to tackle what comes with it, such as improving productivity, choosing the right equipment, and handling stress. The analysis of biological relatedness was performed by calculating relatedness coefficient (r) based on PMR on the autosomal SNPs (Supplementary Data 1.F and Supplementary Information, section4). the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in 1c) and a west Eurasian principal component analysis (PCA) (Extended Data Fig. El Mirn has a significantly higher similarity to theVillabruna clusterthan Fournol 85 and Le Piage II, while the affinity to theVillabruna cluster in Le Piage II is not significantly higher than in Fournol 85 (Supplementary Data 2.D). Curr. Empleos Personas Learning . To obtain Its mainly used in industries such as finance, insurance, healthcare, and insurance-related apps such as credit card applications, vehicle purchasing, etc. To summarize, our results highlight a genetic turnover in the Italian peninsula of the Gravettian-associated Vstonice cluster by the Epigravettian-associated Villabruna cluster that might correlate with discontinuities observed in the archaeological record31. Evol. Lifetime access to all course materials and updates. Dismiss. Commun. Genome Res. The sequence alignment/map format and SAMtools. The mapped reads from the same individual and library set-up were merged and duplications were removed with DeDup. Ancient genomes indicate population replacement in Early Neolithic Britain. I hold a Bachelor's degree at the University of Toronto where I studied pharmacology. The previously described Vstonice cluster, including a newly reported 29,000-year-old individual from Paglicci cave (Paglicci 12) in southern Italy, is closely related to the previously published genomes from Sunghir and Kostenki 12 in western Russia, which are dated to 34ka and 32ka, respectively4,23. Brunel, S. et al. Tina Huang Fans Also Viewed . Tina teaches SQL in data science in addition to this basic material. Individuals with libraries showing signs of contamination were further tested using PMD-filtered bam files. Posth, C., Yu, H., Ghalichi, A. et al. In this period, the Oberkassel-ancestry admixture spread further east, reaching Samara by around 6.5ka, and an increase in Sidelkino ancestry was detected in hunter-gatherers from the Baltic region, which was previously associated with the transition from the Narva culture to the Comb Ceramic culture38,39 (Extended Data Fig. Renaud, G., Slon, V., Duggan, A. T. & Kelso, J. Schmutzi: estimation of contamination and endogenous mitochondrial consensus calling for ancient DNA. The youngest individual carrying large portions of hunter-gatherer ancestry in the analysed dataset is from Ostorf in northern Germany, dated to around 5.2ka (>90% Oberkassel clusterplus Sidelkino-clustercomponents)(Supplementary Data 3.F). Publications 4. h-index 3. Tina Huang Is A Member Of . Taiwan. Nat. Herein, methane is upgraded through the photocatalytic oxidative coupling of methane (OCM) over a ternary Ag-AgBr/TiO 2 catalyst in a pressurized flow reactor. ), Science . I can't believe we finally got to meet in person. Parallel palaeogenomic transects reveal complex genetic history of early European farmers. You can also check out our video on the topic below or scroll down to keep on reading. H. Rougier received support from the College of Social and Behavioral Sciences of CSUN and the CSUN Competition for RSCA Awards. About me. Tina Huang is very empowering, and she knows what she is talking about. Pleistocene North African genomes link Near Eastern and sub-Saharan African human populations. Freshwater radiocarbon reservoir effects at the burial ground of Minino, Northwest Russia. My name is Tina and I'm a data scientist and YouTuber. Hunter-gatherers across the great Adriatic-Po region during the Last Glacial Maximum: environmental and cultural dynamics. Hi! Subsequently, I worked in bioinformatics for a year and then did my Masters in computer science (MCIT) at the University of Pennsylvania. Evol. I hold a Bachelors degree at the University of Toronto where I studied pharmacology. As the coverage for most ancient samples was not sufficient for diploid genotype calling, we counted the reads covering selected phenotypic SNPs on reference or alternative alleles and computed the group-based allele frequencies following a maximum likelihood approach described in Mathieson et al.37. & Hlie, J. F. Temperature and precipitation regime in LGM human refugia of southwestern Europe inferred from 13C and 18O of large mammal remains. Mateja Hajdinjak, Fabrizio Mafessoni, Svante Pbo, D. M. Fernandes, D. Strapagiel, R. Pinhasi, Pavel Flegontov, N. Ezgi Altnk, Stephan Schiffels, Daniel M. Fernandes, Kendra A. Sirak, David Reich, Sandra Oliveira, Kathrin Ngele, Mark Stoneking, Eirini Skourtanioti, Harald Ringbauer, Philipp W. Stockhammer, Vanessa Villalba-Mouco, Marieke S. van de Loosdrecht, Wolfgang Haak, Joseph H. Marcus, Cosimo Posth, John Novembre, Natalija Kashuba, Emrah Krdk, Anders Gtherstrm, Nature I am super excited to join the 365 Data Use Cases series, and in this post, I will share insights about my favorite data use case: product development. The dimensions are calculated using newly reported and previously published hunter-gatherer groups or individuals with more than 30,000 SNPs. 255, 106796 (2021). Feldman, M. et al. Nature 514, 445449 (2014). Extended Data Fig. Ideally, we also want lots of data because this will give us more confidence in our results. PACEA co-authors of this research benefited from the scientific framework of the University of Bordeauxs IdEx Investments for the Future programme/GPR Human Past. In no time, she established herself as one of the favorite vloggers of the data community. . Details on the allele frequency estimates are provided in Supplementary Information, section12, Supplementary Figs. Jan 2022 - Jun 20226 months. This might have been in part triggered by the concomitant expansion of Neolithic farmers across Europe and/or by environmental factors, such as the climatic event around 8.2ka, the largest abrupt cooling in the northern hemisphere during the Holocene epoch46,47. Natural Language Processing (NLP) is another technique that has a well-deserved position in product development. Much attention has b Fluorescent probes targeting specific organelles are useful tools for understanding their intracellular behaviors. Quat. One-time payment. Within Sicily, the 14ka Oriente C individual shows higher affinity with the much younger but geographically closer 10ka Uzzo group30 (n=2) than with the almost contemporaneous San Teodoro 2 individual from eastern Sicily. ISSN 0028-0836 (print). In addition to her rich experience, including bioinformatics cancer research at OICR, Tina is a popular YouTuber with over 60K subscribers. Curr. Yu Ting Wang, Wen Lin Huang, Yan Ting Cheng. Correspondence to eLife 11, e77625 (2022). Este botn muestra el tipo de bsqueda seleccionado. This process allowed us to assign an ancestral or derived haplogroup for covered branches, and to make corrections to calls in cases where, for instance, a more derived haplogroup was called because of residual ancient damage (C-to-T or G-to-A mismatches) in terminal read positions at diagnostic SNPs98 (Supplementary Data 1.A). Both newly sequenced genomes from Solutrean-associated individuals (Le Piage II (23ka) from southwestern France and La Riera (level 14, 21ka) from northern Spain) show a generalized affinity with members of the Fournol and GoyetQ2 clusters in outgroup f3-statistics (Supplementary Data 2.A). In addition to this general data science content, Tina teaches SQL . Shes currently at Microsoft. Billed once. While terms such as lithic industry, techno-complex, prehistoric tradition, and so on might be more appropriate to refer to the various associated chrono-cultural subdivisions, they concern different levels of discussion and are not applicable to all contexts investigated here. As of right now, it doesnt seem that MySQL is the right choice for storing data because the database is so large, it would be impossible to find and query the necessary information. I love learning new things a. In this video @Tina Huang and I go through 5 subscriber submitted resumes and review them. Great explanations and feels like real interviews that helps me warm up myself before the real interview! 116, 105100 (2020). Echinacea, also known as Coneflower, is legendary for a reason: science has shown multiple species of Echinacea can provide potentially broad-reaching support for the innate and adaptive immune system. Questions? The grouping of Epigravettian-associated populations is shown with the same colour in a. Previous studies have shown that two main hunter-gatherer ancestries were predominant across most parts of Europe after around 14kathat is, the western hunter-gatherer (WHG) ancestry, related to the Villabruna cluster, and the eastern hunter-gatherer (EHG) ancestry, showing affinity to both the Villabruna and the ancient north Eurasian (ANE) ancestry found in Upper Palaeolithic Siberian individuals4,36. Laplace, G. Essai de Typologie Systmatique (Annali dellUniversit di Ferrara, 1964). My name is Tina Huang and Im a data scientist at a FAANG company. Fu, Q. et al. Sci. Folding bicycle. Resurrected Supernova Provides Missing-Link, Bald Eagles Aren't Fledging as Many Chicks, Ultracool Dwarf Binary Stars Break Records, Deflecting Asteroids to Protect Planet Earth, Quantum Chemistry: Molecules Caught Tunneling, Shark from Jurassic Period Highly Evolved, 2.9-Million-Year-Old Butchery Site Reopens Case of Who Made First Stone Tools, Gut Microbes Can Boost the Motivation to Exercise, Warmer Climate May Drive Fungi to Be More Dangerous to Our Health, Seawater Split to Produce 'Green' Hydrogen. Instead, in southern Europe, a distinct hunter-gatherer genetic profile was found as early as 17ka in individuals associated with the Epigravettian culture15 (2412ka, from the Italian peninsula to the southeastern European Plain across the Balkans). Runtime Collective Limited (trading as Brandwatch). If you want to know more, you can always go to MySQLs data warehouse site. Natl Acad. The long-lasting genetic continuity in Iberia is also reflected in the preservation until the Mesolithic of Y-chromosome haplogroup C, which was predominant in pre-LGM groups but rarely found after the LGM in other parts of Europe (Extended Data Figs. Sci. These European regions, therefore, constitute climatic refugia where human populations survived during the LGM. Big Data, Data Mining, and Machine Learning (Jared Dean) . Definitely a course worth investing in as it sticks out as a unique course focusing on SQL interviews and doesn't contribute to the abundance of generic courses on the internet! This year they plan on seeing a total of 1,280 entries. Ruiz-Redondo, A. et al. 272273, 354361 (2012). The membrane was able to achieve FRR of 98.73 0.83 % after 4 cycles of filtration, indicating that anti-fouling properties have been enhanced. Error bars show 1s.e.m. 803147-RESOLUTION (to S.T. "Ice Age survivors." One of the best-known and most liked personalities in the data community, Tina is a successful YouTuber and works with one of the FAANG companies. In sum, we describe the formation and interaction between the Oberkassel and Sidelkino clusters, the two main hunter-gatherer ancestries present in Europe from 14ka onwards. (Robert Rueda; Tina Saldivar; Lynne Shapiro; Shane Templeton; Houghton Mifflin Company Staff) 2022-112-4f84b - Ecologizr. In this episode we go through a couple really superb resumes that you should model yours after. Quat. Seguin-Orlando, A. et al. Djindjian, F. Territories and economies of hunter-gatherer groups during the last glacial maximum in Europe. Modern humans began to spread across Eurasia around 45,000 years ago but previous research showed that the first modern humans that arrived in Europe did not contribute to later populations. By co-analysing previously published data with our newly reported genomes associated with the Magdalenian from La Marche (18ka) and Pincevent (15ka) in western and northern France, respectively, and Maszycka (1816ka) in southern Poland, we confirm that the Goyet Q116-1 ancestry survived in all studied Magdalenian-associated genomes besides in Gravettian and Solutrean-associated individuals from southwestern and western Europe (Fig. A Free Service of Your Local Public Library and the Pennsylvania Public Libraries Film Center of the State Library of Pennsylvania Touchstone Pictures In celebration of our twentieth animated feature, we invite you to relive with us the story telling magic, the wit, the wisdom, the humor, the understanding of a very special person who gave the world a timeless and universal art form. Contrary to West Siberian hunter-gatherers, Tutkaul 1 does not carry an extra eastern Eurasian ancestry, but shows affinity to Iranian Neolithic farmers and some younger populations from Iran and the Turan region (Supplementary Data 2.L). However, using f4-statistics, we show that all Magdalenian-associated individuals, and not only El Mirn, carry Villabruna-related ancestry whencompared tothe Fournol cluster(Supplementary Data 2.H). Palma di Cesnola, A. Culturally, however, we see both widespread general tendencies, such as weaponry and some portable art48, and other aspects that have a more regional character, such as mortuary practices (Supplementary Information, section13), various originalities in lithic and hard organic materials tool kits and adornments20,21. Sci. "Unlike diving into the university life directly, the pathways program is a buffer that allows international students to be better prepared. A software engineer who now works as a content creator full-time, Mayuko Inoue runs a YouTube channel dedicated to software engineering, working in the tech industry, and life in general. Besides, the nucleolus is involved in a variety of cellular functions including cell cycle regulation and cellular stress response. PLoS Biol. "With these findings, we can for the first time directly support the hypothesis that during the Last Glacial Maximum people found refuge in the climatically more favourable region of southwestern Europe" says first author Cosimo Posth. We provide five novel insights into the genomic history of hunter-gatherer populations over a time span of 30,000 years from the Upper Palaeolithic to the Neolithic. Our capabilities include CNC machining, sheet metal If material is not included in the articles Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Tina Huang is a statistician who focuses on the statistical modeling and analysis of big data. Soonafter8 ka, Sidelkino ancestry was absent in eastern Spain but it had already reached northern Iberia alongside an increase in Oberkassel ancestry (Fig. Remember, its the problem that defines the tools we use! of Leiden, 2000). Genetics 203, 881891 (2016). For ds_halfUDG libraries, we called genotypes on all targeted sites from 2bp-masked bam files; for ds_nonUDG libraries, we called genotypes on transversion sites only; for ss_nonUDG libraries, we called genotypes with single-strand mode, which ignores forward reads at C/T polymorphisms and reverse reads at G/A polymorphisms. Science 365, eaat7487 (2019). These f4-statistics also confirm that Goyet Q376-3 carries a similar ancestry to Goyet Q116-1 and Kostenki 12 carries a similar ancestry to the Sunghir group, whereas Bacho Kiro 1653 (35ka) from Bulgaria, Muierii 1 (34ka) and Cioclovina 1 (32ka) from Romania, and Paglicci 133 (33ka) from southern Italy are equally related to Goyet Q116-1 and Sunghir. From at least 14,000 years ago, an ancestry related to this culture spread from the south across the rest of Europe, largely replacing the Magdalenian-associated gene pool. Peresani, M. et al. Modern humans have populated Europe for more than 45,000 years1,2. Biol. 15, 22792300 (2020). The generation time is set to 29 years and the error bars show the SE of the admixture date estimated from jackknife resampling (n=22 autosomal chromosomes). The Kostenki (and Sunghir group) ancestry contributed to the previously described Vstonice cluster represented by Gravettian-associated individuals from central-eastern and southern Europe4. 581582, 128163 (2021). Google Scholar. Learn with a sense of purpose. Notes 9, 88 (2016). A similar pattern is observed through the analysis of ROH segments (Extended Data Fig. Klaric, L., Goutas, N., Laccarire, J. Sci. This plot reveals the presence of three distinct groupings: (1) a pre-40ka group with individuals from the UstIshim, Bacho Kiro, Zlat k and Petera cu Oase sites, (2) a Vstonice cluster including Gravettian-associated individuals from centraleastern and southern European sites (Doln Vstonice, Pavlov, Krems-Wachtberg, Paglicci and Ostuni), and (3) a Fournol cluster(hereafter, Fournol cluster or ancestry) comprising Gravettian-associated individuals from western and southwestern European sites (Ormesson, La Rochette, Fournol and two Seriny cave sites (Mollet III and Reclau Viver)). Rohland, N., Harney, E., Mallick, S., Nordenfelt, S. & Reich, D. Partial uracilDNAglycosylase treatment for screening of ancient DNA. The end goal is to create and grow a product that users love. In her journey of eventually becoming a data scientist, Tina started out with an undergraduate in Pharmacology. Straus, L. G. The human occupation of southwestern Europe during the Last Glacial Maximum: Solutrean cultural adaptations in France and Iberia. Sikora, M. et al. & Strimmer, K. APE: analyses of phylogenetics and evolution in R language. 4, 11 (2007). Science 358, 659662 (2017). I'm I've learned SQL before, but I need a refresher. Other proposed climatic refugia for human survival during this period are the Italian peninsula, the Balkans and the southeastern European Plain, but the actual genetic contribution of populations from these regions to post-LGM Europeans is highly debated11,12,13. Karmin, M. et al. Write for us- Weird Science, Energy & Minerals Guest Post. We thus modelled individuals belonging to the GoyetQ2 cluster and El Mirn as a mixture between the Fournol 85 and Arene Candide 16 genomes as proxies to represent the Fournol and Villabruna ancestries, respectively, in Magdalenian-associated groups (Fig. The y axis shows the average of calibrated radiocarbon dates in thousands of years (kyr) (Supplementary Data 1.A). Join now Sign in . Low latency, reasonably low communication overhead and ability to support real time applications are the reasons for . The bivariate plots show the expansion of Oberkassel and Sidelkino ancestries through time in two European areas (longitude below and above 30 degrees). You probably remember me from class or an event, and that's why this profile is so interesting - it traces my journey from student-athlete at the University of California Davis into a successful entrepreneur with multiple ventures under her belt by age 25, Your email address will not be published. Citing . This is one of the things that make us stand out from other platforms which usually consider mathematics and statistics a prerequisite. Grizz, Panda i Lodomir maj rne charaktery, ale pomimo odmiennoci potrafi wspdziaa i wspiera si w kopotach. Nat. The genomic history of the Iberian Peninsula over the past 8,000 years. 101019659 (to K.H.). It is generated automatically, and you can download, view, and share it at any time. 14 following. Publishers note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Pleistocene mitochondrial genomes suggest a single major dispersal of non-Africans and a Late Glacial Population turnover in Europe. Hi! Become an in-demand #DataScience professional TODAY with the 365 Data Science Program -> https://365datascience.com, analyzing similar products to compare how they performed, data visualizations with SQL and Python or R. Separating endogenous ancient DNA from modern day contamination in a Siberian Neandertal. Ecol. For the SNP associated with light eye colour (HERC2/OCA2 (rs12913832)), individuals from the Villabruna cluster,Oberkasselcluster, Baltic HG and SHG groups show high frequencies of the derived allele (>90%), which is responsible for the green or blue eye phenotype, whereas Sidelkinocluster, Ukraine HG and Iron Gates HG groups show low occurrence of this allele (1025%). The latter was created as a support network for women in the industry to discuss, share, and learn from each other.. Notably, this genetic distinction coincides with dissimilarities in mortuary practice among genetically analysed Gravettian-associated individuals from different parts of Europe. Skoglund, P. et al. A dynastic elite in monumental Neolithic society. Also if you want to see some cat pics. Dolukhanov, P. in Cultural Transformations and Interactions in Eastern Europe (eds Chapman, J. 7 Admixture dates between Oberkassel/Villabruna and ANE ancestries in the oldest individuals from the Sidelkino cluster. Extended Data Fig. PubMed This often involves analyzing similar products to compare how they performed. Protoc. F4-statistics further support this view, revealing that Le Piage II is more closely related to the Fournol clusterthan the Vstonice cluster (f4(Mbuti, Le Piage II; Vstonice, Fournol 85)0, Z=6.58). B 370, 20130624 (2015). All enrolled students have access to course exams no matter how many lessons they have watched in a course. Rohland, N., Glocke, I., Aximu-Petri, A. 31, 24842493.e7 (2021). Yang, M. A. et al. Raghavan, M. et al. Edit your profile. Jodie Sweetin. (grey) of the f4 values estimated from 5cM-block jackknife analysis. USA 117, 1279112798 (2020). 2, 17561762 (2007). Ice Age survivors. All remains were sampled with the approval of the institutions responsible for the analysis of archaeological material. And if youre new to data science, check out the 365 Intro to Data and Data Science course. & Ringbauer, H. hapCon: estimating contamination of ancient genomes by copying from reference haplotypes. The purified products were amplified in multiple 100l reactions using Herculase II Fusion DNA Polymerase (Agilent) following the manufacturers specifications with 0.3M of the IS5/IS6 primers. Nucleic Acids Res. Claim Author Page. In practice, we use machine learning in different conjunctures. CAS In addition to her data science work, Tina has also created the popular popular game Code Wars. Instagram has an infinite scroll, and Uber has different options such as UberXL and Uber Pool. This course is the perfect balance of teaching technical SQL concepts and optimal approaches to solving coding questions on interviews. My name is Tina and I'm a data scientist and YouTuber. 46, 6584 (2020). From around 8ka, we begin to observe admixture events with Sidelkino ancestry in central Europe. Hi, my name is Tina and I'm a data scientist at a FAANG company. An early modern human from Romania with a recent Neanderthal ancestor. We built 1 to 8 single- and double-stranded genetic libraries for each individual and enriched them for human DNA on 1.24million single nucleotide polymorphisms6 (SNPs), which were then sequenced and yielded 0.04- to 7.64-fold coverage on average over the targeted SNPs. 10, 552010 (2019). 2014-2020.4.01.16-0030) and C.L.S.